Peripheral T - cell Lymphoma in ZckPr - bcZ - 2 Transgenic Mice
نویسندگان
چکیده
t(14;18) is the most common translocation in human lymphoid malignancy and results in bcl-2 overexpression. bcl-2 blocks apoptosis and constitutes the initial member of a new catagory of oncogenes, ie, regulators of cell death. Bc/-2-/g transgenic mice develop follicular hyperplasia and progress to malignant B-cell lymphoma. To assess the oncogenic potential of bcl-2 in the T-cell lineage, a cohort of 68 /cP"bcl-Z transgenic mice and 56 control littermates were monitored for signs of malignancy over a 24-month period. Eighteen (26%) /cP"bc/-2 mice developed diffuse, predominantly largecell lymphomas at a mean age of 18 months.
منابع مشابه
Peripheral T-cell lymphoma in lckpr-bcl-2 transgenic mice.
t(14;18) is the most common translocation in human lymphoid malignancy and results in bcl-2 overexpression. Bcl-2 blocks apoptosis and constitutes the initial member of a new category of oncogenes, ie, regulators of cell death. Bcl-2-Ig transgenic mice develop follicular hyperplasia and progress to malignant B-cell lymphoma. To assess the oncogenic potential of bcl-2 in the T-cell lineage, a co...
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